Stronghold cats (5 to 10 kg) pipette (1 ml) drops on the withers

Strongkhold Stronghold of a cat (from 5 to 10 kg) the pipette (1 ml) of a drop on withers of Strongkhold Plus (Drops for external application, pointed drawing) Opisaniye: Solution for external application in plastic tubas. Sostav: 1 ml of medicine contains active ingredient: selamektin - 60 mgsarolaner - 10 mg. Excipients: propylene glycol monomethyl air, isopropyl alcohol, butylhydroxytoluene. Pharmacological properties: ATCvet QP54, endektotsidy (QP54AA05, selamektin, macrocyclic lactones) Selamektin - group substance endektotsidiv a class of macrocyclic lactones. the mechanism of action is connected with change of activity of chloric channels synoptic a membrane the nervous and muscular systems of many ektoparazit. Contacting specific receptors, it increases permeability of synoptic membranes for chlorine ions that leads to blockade of electric activity of nervous and muscle cells of parasites, and, as a result, to their paralysis and death. At mammals the similar receptors are located only in the central nervous system. as selamektin has no ability to get through a hematoencephalic barrier, it is the high level of safety, in the recommended doses it is safe for dogs and cats. Selamektin shows a wide range sistemnog nematodotsidno, insecticidal and acaricide action, has larvotsidn and ovotsidny properties. Preparat is quickly and completely soaked up from the place of drawing in blood. therapeutic concentration to a selamektin in blood are maintained a long time, providing extermination of parasites and protection against an invasion within a month. Sarolaner is an acaricide and an insecticide which belongs to group to an izoksazolin. the main subject to action sarolaneru at insects and akarid is functional blockade a ligand - dependent chloride channels (GAMK-receptors and glutamate receptors). Sarolaner blocks GAMK-i a glutamate - dependent chloride channels in the central nervous system of insects and akarid. violation by a sarolaner of work of these receptors interferes with absorption of ions of GAMK-i chlorine glyutamat dependent ion channels that leads to increase in nervous stimulation and death of a target parasite. Sarolaner shows higher functional ability to block receptors of insects / akarid to comparison with receptors of mammals. Sarolaner does not interact with the known insecticidal sites of binding nicotinic or others GAMK-ergicheskikhinsektitsidov, such as neonicotinoides, fipronit, milbemitsin, avermektina and cyclodienes. Sarolaner it is effective against adult fleas (Ctenocephalides spp.), A also against some species of ticks, for example, Dermacentor reticulatus, Ixodes hexagonus, Ixodes ricinus Rhipicephalus sanguineus. After local putting medicine of Strongkholda Plus as selamektin, and a sarolaner 40.5% and 57.9% are well soaked up with average values of bioavailability, respectively, and are distributed systemically. At cats selamektin and a sarolaner 12.5 days and 41.5 days after local drawing are medicines with the low level of clearance and long elimination half-life, respectively. At cats the main way of removal to a selamektin - with a stake, the majority is removed in the form of initial connection. Identification of metabolites to a selamektin in Calais showed that the metabolic clearance also promotes its removal. The main way of removal to a sarolaner is elimination with bile of initial connection taking into account metabolic clearance. Application: Treatment and prevention of defeat of a parazitiformnima pincers: Ixodes spp. Dermacentor spp. and Rhipicephalus spp. Prevention and treatment of a toksokaroz (Toxocara cati), ankilostomoz (Ancylostoma tubaeforme), an otodektoza (Otodectes cati), a felikolyoza (Felicola subrostratus), a sifonapteroza (Ctenocephalides spp., Pulex irritans), also Preparat can be performed by a to prevention of a dirofilyarioz (Dirofilaria immitis) as a part of therapeutic strategy for treatment of the allergic dermatitis caused by fleas (FAD). Dosage: Preparat apply to dry skin cats between shovels in the following doses: The weight of a cat Obyem of the pipette (ml) Selamektin (mg) Sarolaner (ml) up to 2.5 kg 0.25 ml 15 mg 2.5 ml from 2.5 to 5 kg 0.5 ml 30 mg 5 ml from 5 to 10 kg 1 ml 60 mg 10 ml Extermination of fleas and kleshcheycherez 24 hours and within 5 weeks after putting medicine the adult fleas and pincers which are on an animal perish. Preparat breaks ability of fleas to lay viable eggs and destroys larvae which are in the external environment. It breaks off a cycle of reproduction of fleas and allows to control the available environmental pollution where there is an animal. Dlya of prevention of an invasion medicine has to be applied during the season of activity of fleas and ticks once a month. Dl uses of medicine as compound therapy at flea allergic dermatitis apply medicine with a monthly interval. Treatment of a toksokaroz and ankilostomozanuzhno to apply a single dose of medicine. Need and frequency of repeated treatment should be coordinated with the treating veterinarian who appoints medicine. Treatment otodektozapreparat is performed once. Before treatment it is recommended to clean acoustical pass from exudate and scabs. If necessary the course of treatment is repeated in a month. Treatment pedikulezapreparat is performed once. Prevention dirofilyariozadlya prevention of a dirofilyarioz of Strongkholda Plus appoint an animal of every month, beginning a month before the beginning of summer of carriers of the activator - Komarov / mosquitoes and finish not earlier than in a month after end to summer of insects. In case the monthly interval between two uses of Strongkholda Plus was broken, medicine is applied at once as with such opportunity is that minimizes a possibility of development of mature dirofilyariya. In case of use of other medicine for prevention of a dirofilyarioz, the subsequent use of medicine of Strongkholda Plus is carried out in a month after the last use of the previous medicine. ProtivopokazaniyaN to apply at animals with the reduced body weight and also the exhausted and sick animal. To apply Ne at hypersensibility to acting or excipients. Caution Preparat is intended only for external skin application. Strongkhold Plus is recommended to apply to cats aged from 8 weeks and weighing not less than 1.25 kg. Ne to apply medicine to moist skin. It is impossible to bathe animals during 2:00 after putting medicine before full drying). At treatment of an otodektoz, medicine does not need to be applied directly in an ear canal. In a case ingestion or a slizyvaniye of a significant amount of medicine it can be observed temporary phenomena from digestive tract, such as the increased salivation, vomiting, soft excrements or small appetite. Usually they pass without treatment. Not to allow the processed animals close to naked flame or other sources of ignition within not less than 30 minutes before full drying of wool. It is forbidden to smoke, drink or eat food in operating time with medicine. To store far from sources of heat and fire. After processing of animals carefully to wash up hands with soap. At accidental hit of medicine in eyes to wash with flowing water, at hit on skin immediately to wash away water with soap and to see a doctor. To allow children to play Ne with the processed cats during 4:00 after treatment. It is recommended to process animals in the evening. In day of treatment, the processed animals should not allow to sleep in one bed with the owner, especially children. People with sensitive skin or the established allergy to veterinary medicines of an etogotip should behave with care at application of Strongkholda Plus. Application during pregnancy or the laktatsiibezopasnost of medicine was not established during pregnancy and a lactation, or at the animals intended for cultivation. However selamektin is safe for use at are divorced, at pregnant women and the lactating cats. Safety to a sarolaner was not estimated at are divorced, at pregnant women and the lactating cats, but laboratory researches on a sarolaner at rats and rabbits did not show teratogenny effect. Therefore application of Strongkholda Plus has to be based on the assessment advantage risk carried out by the veterinarian who appoints medicine. Collateral the reaktsiiprimeneniye of Strongkholda Plus can cause a slight itch in the place of drawing. the easy or moderate alopetion in the place of drawing, an eritem and salivation was sometimes observed. The form vypuskapreparat is issued in one - the dosed plastic tubas in aluminum blister software packages 0.25; 0.5; 1.0 ml. Secondary packing - the cardboard boxes containing three the blister packages with tubas. The SberezhenieSuhyy place at a temperature not higher than 30 "page. To freeze Ne! To take out the pipette from the blister only just before use. Dlya of application in veterinary medicine Proizaoditel: Zoetis Inc., SShAdata editing description: 16.03.2020