Potassium orotat tab. of 500 mg No. 10

Translation of the instruction Mose

OROTAT POTASSIUM of a tablet of 500 mg

Instruction

On medical use of medicine

Potassium orotat

Ingredients:

Active ingredient: potassium orotat;

1 tablet contains potassium of the orotat 500 mg;

excipients: lactose, monohydrate; gelatin; stearic acid; potato starch.

Dosage form.

Tablet.

Main physical and chemical properties: integral correct, round cylinders, the top and lower surfaces of which flat, edges of surfaces mown, with a notch for division, white color.

Pharmacotherapeutic group.

Anabolic means for system application. nonsteroid anabolic means.

ATX A14B Code.

Pharmacological properties.

Pharmacodynamics.

orotat the general stimulating influence on exchange processes has

Potassium, participates in proteinaceous and carbohydrate exchanges. The basic structural element of potassium of the orotat is orotovy acid.

Acid orotovy provides to

synthesis of the pirimidinovy bases (uracil, thiamine, a tsitozin) in the course of synthesis of the nucleic acids participating in synthesis of proteinaceous molecules. As a result of participation in carbohydrate metabolism, acid orotovy normalizes exchange of a galactose.

Potassium orotat as anabolic means is applied to restoration of violations of protein metabolism and stimulation of processes of metabolism.

Pharmacokinetics.

it was not investigated by p.

Clinical characteristics.

Indication.

Complex therapy of diseases of a liver and the bilious ways caused by acute and chronic intoxications (except liver cirrhoses with ascites), dystrophies of a myocardium, a myocardial infarction, chronic heart failure of ii-iii of a stage, arrhythmias (ekstrasistoliya), an alimentary and alimentary and infectious hypotrophy at children, the progressing muscular dystrophy, anemia, a galactosemia, a dermatosis.

is Applied also at the increased physical activities and during recovering from a serious illness.

Contraindication.

Hypersensitivity to active ingredient and to other components of medicine. cirrhosis with ascites, the sharp and expressed chronic kidney disease, a lymphogranulomatosis, malignant diseases of bodies of blood formation, a hyperpotassemia.

Interaction with other medicines and other types of interactions.

Efficiency of potassium of the orotat increases at simultaneous application with folic acid and cyanocobalamine.

Potassium orotat is improved by tolerance of cardiac glycosides (for example digoxin, Celanidum).

At simultaneous application with kaliysberegayushchy diuretics, inhibitors of angiotensin-converting enzyme (APF) the development of a hyperpotassemia is possible

.

can use Drug along with vitamins, cardiotonic medicines.

Knitting and enveloping means (for example-nol, sukralfat, algeldrat, magnesium hydroxide, bismuth medicines) can reduce several orotat potassium absorption in a digestive tract.

At simultaneous application with glucocorticosteroids, insulin, muscle relaxants, oral contraceptives the efficiency of orotovy acid decreases.

Feature of application.

Potassium orotat cannot be applied to kaliyzamestitelny therapy.

Potassium orotat should not be applied at meal time in connection with a possibility of its interaction with food components.

Drug contains lactose therefore its application is contraindicated to patients with rare hereditary states, such as intolerance of a galactose, insufficiency of lactase, a syndrome of glyukozo-galaktozny malabsorption.

to

If at you established intolerance of some sugars, consult with the doctor before accepting this medicine.

Use during pregnancy or feeding by a breast.

Use of medicine during pregnancy is only possible

when the expected advantage for mother exceeds potential risk for a fruit.

In need of use of medicine needs to stop feeding by a breast.

Ability to influence speed of response at control of motor transport or other mechanisms.

does not influence.

Route of administration and doses.

Potassium orotat is accepted inside in 1 hour prior to food or in 4 hours after a meal. swallow of tablets without chewing, washing down 150–200 ml of water.

Adult are appointed on 250–500 mg by 2–3 times a day. The daily dose makes 0.5 mg — 1.5 g. In some cases, in need of increase in therapeutic effect, the daily dose for adults is increased to 3 g

Course of treatment — 3–5 weeks, if necessary the course of treatment is repeated in a month.

by

to Children from 5 years of potassium orotat appoint 10–20 mg/kg of body weight in a daily dose. The specified daily dose is divided into 2–3 receptions.

Children.

is not recommended to be applied to children under 5 years.

Overdose.

by

At long application observe an allergic dermatosis that demands performing the desensibilizing therapy; the hyperpotassemia demanding medicament withdrawal.

in case of application in high doses at observance of a diet with low protein content the development of dystrophy of a liver is possible

that demands medicament withdrawal and the corresponding therapy.

strengthening of side effects Is possible

.

Side reactions.

Drug is usually well transferred by

. allergic reactions (including dermatitis, skin rashes) and dispeptic reactions (including nausea, vomiting, diarrhea) which quickly take place at medicament withdrawal are in some cases possible.

in case of application in high doses at observance of a reduced-protein diet the development of fat dystrophy of a liver is possible

.

development of the hyperpotassemia which is followed by paresthesias, changes of indicators of the ECG Is possible

.

Expiration date.

4 years.

Storage conditions.

to Store

in original packing at a temperature not above 25 °C.

to Store

out of children's reach.

Packing.

On 10 tablets in blisters.

Category of a holiday.

Without recipe.

Producer.

PJSC lubnyfarm.

Location of the producer and address of the venue of its activity.

Ukraine, 37500, Poltava Region, of a lubna, st. of a barvinkov, 16.