Miramistin solution for an external comment 0.1mg/ml fl. 50 ml

Pharmacological properties

Pharmacodynamics. the direct hydrophobic interaction of a molecule with lipids of membranes of microorganisms leading to their fragmentation and destruction is the cornerstone of action of a miramistin. at the same time a part of a molecule of a miramistin, plunging into the hydrophobic site of a membrane, destroys a nadmembranny layer, loosens a membrane, increases its permeability for high-molecular substances, changes fermental activity of a microbic cell, inhibiting fermental systems that leads to oppression of activity of microorganisms and their cytolysis.

Unlike other antiseptic agents, miramistin has sharp selectivity of action concerning microorganisms as practically does not affect covers of cells of the person. This effect is connected with other structure of cellular membranes of the person (considerable the bigger length of the lipidic radicals which are sharply limiting a possibility of hydrophobic interaction of a miramistin with cells).

Miramistin possesses the expressed antimicrobic action concerning gram-positive and gram-negative, aerobic and anaerobic, spore-forming and asporogenic bacteria in the form of monocultures and microbic associations, including hospital strains.

perniciously on causative agents of diseases, sexually transmitted: gonokokk, pale treponemas, trichomonads, chlamydias and also on viruses of herpes, an immunodeficiency of the person. Has antifungal effect on ascomycetes of the sort Aspergillus and the sort Penicillium, barmy (Rhodotorula rubra, Torulopsis gabrata, etc.) and yeast-like (Candida albicans, Candida tropicalis, Candida krusei, etc.) mushrooms, on dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton schoenleini, Trichophyton violaceum, Epidermophyton Kaufman-Wolf, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis, etc.) and also on other pathogenic fungi (for example Pityrosporum orbiculare (Malassezia furfur)) in the form of monocultures and microbic associations. Under the influence of a miramistin the resistance of microorganisms to antibiotics decreases.

Pharmacokinetics. At topical administration it is not soaked up through skin and mucous membranes.

Indication

Surgery, traumatology: topical treatment of contaminated wounds of various localization and etiology; prevention of consecutive infection of the granulating wounds.

Combustiology: treatment of burns of II and IIIA of degree; preparation of burn wounds for dermatoplasty.

Obstetrics and gynecology: prevention and treatment of suppurations of postnatal wounds, wounds of a crotch and vagina; postnatal infections; inflammatory diseases of genitals (vulvovaginitis).

Dermatology: complex treatment of candidiases of skin and mucous membranes, mycoses of feet and big folds.

Venereology: for individual prevention of diseases, sexually transmitted (syphilis, gonorrhea, genital gepres).

Otolaryngology: complex treatment of sharp and chronic otitis, antritis, tonsillitis.

Stomatology: treatment of periodontitis, stomatitis, hygienic processing of removable prostheses, prevention of microbic complications after surgeries on a mucous membrane of an oral cavity.

Use

is Applied locally at adults.

Surgery, traumatology, Combustiology. With the preventive and medical purpose Miramistin irrigate a surface of wounds and burns, rykhlo tampon a wound and the fistular courses, fix the gauze tampons moistened with an antiseptic agent. The medical procedure repeats 2–3 times a day for 3–5 days. The method of active drainage of wounds and cavities with a daily expense about 1 l of medicine is effective.

Obstetrics and gynecology. For the purpose of prevention of a postnatal infection it is applied in the form of vaginal irrigations before childbirth (5–7 days) and in the form of the intra vulval pads moistened with 50 ml of medicine, after the delivery with exposure of 2 h for 5 days.

by intra vaginal introduction of tampons with medicine for 2 weeks, processing of skin of external genitals and also a medicine electrophoresis.

Dermatology. Treatment of candidiases of skin and mucous membranes, mycoses of feet and big folds is performed by irrigation by means of a raspylitelny nozzle, 3-4-fold pressing or appliques 2–4 times a day.

Venereology. For individual prevention of diseases, sexually transmitted, solution of a miramistin is effective if it is applied no later than 2 h after sexual intercourse. Bottle contents by means of an urethral nozzle are entered into an urethra — to 2-3 ml (men), 1–2 ml (women), into a vagina — 5–10 ml for 2–3 min. After the procedure the bladder emptying for 2 h is not recommended. Process leather of an internal surface of hips, a pubis, external genitals.

Otorhinolaryngology. In purulent antritises during a puncture the genyantrum is washed out by 10 ml of medicine. At treatment of tonsillitis and laryngitis carry out reusable rinsings of a throat by Miramistin's solution. In otitises the tampon moistened with medicine is entered into external acoustical pass of 4-6 times a day for 10–14 days.

Stomatology. At treatment of parodontit, solution of a miramistin is entered into parodontalny pockets on turundas with the subsequent appliques on a gum for 15 min. At aggravations carry out washing of parodontalny pockets by Miramistin by means of the syringe and enter into a turunda abscess cavity with medicine. After carrying out a vestibuloplastika and a frenulektomiya, medicament is used in the form of baths in out-patient conditions. For the purpose of hygienic processing of removable prostheses the last leave for the night in solution of a miramistin, before use the prostheses carefully wash with flowing water.

Contraindication

Individual hypersensitivity to a miramistin.

Side effects

In some cases perhaps short-term burning sensation which is disappearing spontaneously through 15–20 with and not demanding medicament withdrawal. reactions of hypersensitivity, including phenomenon of local irritation of skin: itch, hyperaemia, burning sensation, xeroderma.

Special instructions

Venereology. when processing miramistiny an urethra, a vagina, the internal surfaces of hips, a pubis and external genitals urination during 2 h

Use during pregnancy and feeding by a breast. As the medicine resorption almost completely is absent, Miramistin during pregnancy and feeding by a breast is allowed to apply.

Children. As there is no sufficient experience of use of solution of a miramistin for treatment of children, it is not applied in pediatric practice.

Ability to influence speed of response at control of vehicles or work with other mechanisms. Use of medicine is characterized by lack of influence on ability to steer vehicles or to be engaged in other potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.

Interaction

At the combined application with antibiotics noted decrease in resistance of microorganisms to the last.

Overdose

.

Storage conditions

In original packing at a temperature not above 30 °C. not to freeze.