Linex kaps. No. 32

Structure and form of release

Structure

Active ingredients: 1 capsule contains not less on July 1,2 × 10 WHICH antibiotikorezistentny lactobacilli: not less on June 4,5 × 10 WHICH Lactobacillus acidophilus (sp. L. gasseri), not less on June 3,0 × 10 WHICH Bifidobacterium infantis, not less on October 4,5 × 6 WHICH Enterococcus faecium;

Excipients: lactose, potato starch, dextrin, magnesium stearate

Cover: gelatin, titan dioxide (E 171).

release Form

solid capsules.

Pharmacological properties

Pharmakodinamichesky parameters. As a part of the combined medicament линекс® — three various species of the lactobacilli which are present at different intestinal departments and representing natural intestinal microflora. The specified lyophilized microorganisms keep viability in a digestive tract, rendering assistance and adjusting physiological balance of an intestinal microbiota.

Creation of low values rn in an intestines gleam thanks to process of a metabolization of lactose lactobacilli causes optimum efficiency of digestive enzymes and limits growth and reproduction of causative and opportunistic organisms. Lactobacilli maintain the specified effect by products of bacteriocines — substances with antimicrobic action and also due to activization of a humoral link of the immune system and mechanisms of local protection, an obstacle of adhesion of pathogenic microbes to an intestinal wall. Besides, lactobacilli are necessary in processes of metabolism of bilious pigments and acids in an organism, are sources of vitamins K and

Disorder of physiological balance of intestinal microflora results from group B.

Lakto- and a bifidobacterium the first colonize a GIT. For a number of reasons configuration of normal structure of an intestinal microbiota at newborns can be late, causing emergence of the increased gas generation in intestines, dispeptic disorders, defecation disturbances. Use with the preventive or therapeutic purpose of lactobacilli as a part of capsules of Linex ^® ensures safety of a homeostasis of intestines, giving regulation and support natural balance of an intestinal microbiota.

Pharmacokinetic parameters. After introduction of per os the lactobacilli show local effect in a GIT. Studying pharmacokinetic parameters was not carried out as absorption in a system blood stream does not happen.

Results of preclinical trials testify to safety of drug, absence at it toxic, cancerogenic, mutagen and teratogenic properties.

Indication

Complex therapy of an intestinal disbioz; prevention and therapy of diarrhea of a virus or bacterial etiology (including "diarrheas of travelers") and also the diarrhea associated with use of chemotherapeutic drugs.

Contraindication

Hypersensitivity to medicament components.

Use

during meal. Single dose: children are aged younger than 2 years — on 1 capsule; children at the age of 2–12 years — on 1–2 capsules; children are aged more senior than 12 years and adults — on 2 capsules. frequency rate of reception: 3 times a day.

is not combined with hot or alcoholic beverages.

At impossibility of ingestion by the child of the whole capsule its contents is poured out in liquid (volume — 1 teaspoon) which needs to be accepted immediately.

use Duration — before improvement of a condition of the patient (is defined by an etiological factor of a disease and individual characteristics of an organism).

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Special instructions

in case of fever it is above 38 °C, diarrhea duration more than 2 days, of the profound diarrhea with eksikozy and degrowth of a body, emergence of slime or occult blood in a chair, abdominal pain; in the presence at the patient of chronic pathology, such as cardiovascular diseases or diabetes, immunodeficiency it is necessary to see a doctor for consultation prior to medicament use.

Only under medical observation there has to take place therapy by the medicament Linex ^® at children aged 6 years are younger.

Linex of ^® cannot be accepted the patient with a syndrome of disturbance of absorption in a GIT of glucose and a galactose, a galactosemia or a lactose intolerance (1 capsule of medicament contains 98.28 mg of lactose).

Period of pregnancy and feeding is not recommended to

Due to the insufficiency of information on safety of use for pregnant women and the patients nursing use of medicament at this category by a breast

does not have

information on impact on speed of response at control of vehicles or other mechanisms.

development of allergic reactions in view of the content of insignificant amount of proteins of cow's milk in medicament Is possible

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Overdose

Is not present information.

Side effects

reactions of hypersensitivity, an itching, rashes.

Interaction

. Perhaps combined use with antimicrobial drugs. The desirable span between oral administration of the specified medicaments and the subsequent reception of capsules Linex of ^® has to be 3 h

Storage conditions

In original packing at a temperature of ≤25 °C in the place inaccessible for children. The bottle with capsules has to be densely closed. To use capsules within 4 months from the moment of opening of a bottle.