Kvayt solution shouted. fl. 100 ml

Pharmacological properties

Pharmacological active components of medicine are guayfenezin and the herbs extract having mainly calming effect. the calming influence of extract is combined with myorelaxation action of a guayfenezin (relaxes unstriated muscles).

in a GIT, metabolized in a liver by conjugation with glucuronic acid and allocated in the form of inactive metabolites, mainly with urine.

Indication

Easy form of a neurasthenia, especially if it is followed by concern, fear, grief, restlessness, irritability, obtusion of attention or fatigue, a sleep disorder, insomnia, exhaustion or neurotic memory violations. maintenance therapy at migraine, the headache caused by nervous tension, vascular psychosomatic disorders with a neurocircular asthenia, neuromuscular excitability, pain in a face, at a menopausal syndrome. functional diseases of a digestive tract (dispeptic syndrome, syndrome of the angry intestines). psychosomatic dermatosis which is followed by an itch (urticaria, atopic eczema).

Use

are Usually appointed on 5 ml (1 teaspoon) of medicine by 3 times a day. if necessary it is possible to raise a dose to 10 ml 3 times a day or to lower to 2.5 ml in the morning and in the afternoon and 5 ml — in the evening. the dose can be changed according to a condition of the patient.

Interval between receptions of separate doses has to make from 4 to 6 h. The maximum daily dose — 30 ml.

Drug can be mixed with drinks (juice, tea).

Contraindication

Hypersensitivity to the operating components or excipients of medicine, a myasthenia gravis, epilepsy.

Side effects

Kvayt it is well transferred by patients, however the following side reactions are possible:

from nervous system: seldom — dizziness, drowsiness;

from a digestive tract: seldom — nausea, vomiting, spasms, heartburn, a diarrhea or a lock;

from skin: seldom — a dieback, an itch;

from a musculoskeletal system: seldom — slight muscle weakness;

general frustration: seldom — fatigue.

Special instructions

during use of medicine the patients, especially with light skin, have to avoid long influence of ultraviolet radiation (solar bathtubs, a sunbed, a diathermy).

Should use with care medicament at a serious illness of a liver, intoxication the substances oppressing action of central nervous system.

11.72 about. the ethanol %, one dose (2.5 ml) contains 0.231 g of ethanol that it is necessary to consider at application during pregnancy, feeding by a breast, to children and risk groups (patients with liver diseases, epilepsy, alcoholics).

Drug is contraindicated to persons with rare hereditary intolerance of fructose or glyukozo-galaktozny malabsorption.

Use during pregnancy and feeding by a breast

Pregnancy. Researches of reproductive functions during use of medicine were not conducted; safety of use of medicine during pregnancy is not established. In this regard it is possible to appoint the medicine Kvayt during pregnancy only in exceptional cases. Before its application, especially in І a trimester, it is necessary to estimate a ratio of potential risk for a fruit and the expected advantage for the pregnant woman.

Feeding by a breast. It is unknown whether it is allocated guayfenezin and other active components of medicine in breast milk therefore it is necessary to compare carefully potential risk of influence of medicine on the child and possible advantage for mother.

Ability to influence speed of response at control of vehicles or work with other mechanisms. In consecrate with the fact that Kvayt contains ethanol and guayfenezin, its application can lead to slowing down of reaction that is shown individually at each patient. Therefore it is worth abstaining from potentially dangerous types of activity requiring special attention such as control of vehicles or work with other mechanisms.

Children. Drug is used at children aged from 12 years.

Interaction

Guayfenezin enhances analgeziruyushchy effect of paracetamol and acetylsalicylic acid and strengthens influence of alcohol and other substances oppressing central nervous system. muscle relaxants of the central action can enhance undesirable effects of a guayfenezin, especially muscle weakness.

St. John's wort perforated can cause induction of isoenzymes 3A4, 1A2 and 2C9 of P450 cytochrome that can weaken effect of other at the same time used medicaments which are metabolized by these isoenzymes. The specified action can be also caused by ability to induction of the intestinal transport system the R-glycoprotein. This interaction was for the first time revealed at healthy volunteers at simultaneous application of an indinavir and a St. John's wort perforated. It is also possible to expect that similar interaction happens also to other inhibitors of retrovirus protease (aprenavir, nelfinavir, ritonavir, sakvinavir) and also not nucleotide inhibitors of reverse transcriptase (delaverdin, efavirenz, not Virapinum) which apply at treatment of HIV-1-positive patients. At the combined use of antiretroviral medicines and a St. John's wort perforated there is a weakening of their action to possible emergence of resistance. Therefore the St. John's wort is not applied along with these medicines.

at a concomitant use of cyclosporine, digoxin and warfarin. Interaction can lead to decrease in concentration of medicines in blood plasma and, respectively, to reduction of expressiveness of therapeutic action. Therefore the St. John's wort cannot be applied with cyclosporine. If the patient applies cyclosporine, then it is necessary to cancel reception of a St. John's wort and, considering cyclosporine level in blood plasma, to otkorrigirovat a cyclosporine dosage.

. If purpose of a St. John's wort is necessary, carry out monitoring of level of digoxin in blood plasma or control of the prothrombin ratio during treatment with warfarin, the dose should be changed respectively. When the dose of warfarin or digoxin is raised, the dose of a St. John's wort is not changed.

St. John's wort perforated can reduce considerably effect of theophylline therefore simultaneous application is not recommended. In need of reception of a St. John's wort it is required to control theophylline level in blood plasma and in case of need — to korrigirovat a theophylline dose, without changing a St. John's wort dose.

Simultaneous application with oral contraceptives can cause violation of a menstrual cycle, bleeding and also decrease in efficiency of medicine. Therefore simultaneous application of a St. John's wort and oral contraceptives is not recommended.

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Influence on results of laboratory analyses.

Guayfenezin can cause false positive results of diagnostic tests at which define 5-hydroxyindolacetic acid (a photometric method with use of a nitrozonaftol as reagent) and vanilmindalny acid in urine. Therefore the Kvayt medicament treatment needs to be stopped for 48 h before collecting urine for carrying out this analysis.

Overdose

At first is shown by oppression of central nervous system, drowsiness. later these symptoms can be followed by nausea, slight muscle weakness, a joint pain and heavy feeling in a stomach.

Treatment exclusively symptomatic also corresponds to the general principles of treatment at overdose. There is no specific antidote.

Storage conditions

At a temperature not higher than 25 os. not to freeze. to store out of children's reach.