Biolektra Magnezium Forte of the tab. thorn. 243 mg No. 10

Pharmacological properties

Magnesium is an important element for a metabolism in an organism. he is necessary for ensuring many power processes, participates in exchange of proteins, fats, carbohydrates, nucleic acids and in the course of neuromuscular excitement.

Numerous functions of generation or expense of energy (for example oxidizing phosphorylation or the ionic pump, reduction of muscles) depend on magnesium, and at its shortcoming can be broken partially or completely.

Magnesium activates glycoclastic enzymes, enzymes of cellular oxidation, enzymes of synthesis of nucleic acids, it also plays an important role in processes of reduction of a myocardium, is the stabilizer of fibrinogen and thrombocytes. It is known that the deficiency of magnesium is one of the reasons of development of AG, an angiospasm, neoplastic diseases and an urolithiasis. In stressful situations the increased amount of the free ionized magnesium is removed therefore the additional amount of magnesium promotes increase in resistance to a stress. Magnesium plays the leading role in processes of neuromuscular excitement, acting as the antagonist of calcium ions.

Total amount of magnesium in an organism of the adult makes about 20-30 g. From this quantity about 50% contain in bones, 45% — in cells and only 5% of total can be defined in blood plasma.

ranging from 10 up to 60 mmol/l, the normal value of concentration of magnesium is in blood plasma ranging from 0.7 up to 1.1 mmol/l. In blood plasma approximately ⅔ ions of magnesium are in the dissolved look and near ¹ / ₃ contacts proteins.

At use depending on the initial content of magnesium in an organism. At deficiency of magnesium in an organism its bigger quantity is soaked up, and at saturation by magnesium — smaller. The ratio of a resorption corresponds to homeostatic adjustable kinetics of a resorption characteristic of physiologically active agents.

At equilibrium balance of magnesium and normal function of kidneys, even at high doses of magnesium its accumulation exceeding limit of norm does not happen.

After absorption in intestines with kidneys. Undigested magnesium is removed with a stake.

Indication

Treatment and prevention of deficiency of magnesium in an organism when it is the reason of disturbances from muscle performance (neuromuscular disturbances, spasms), at chronic physical and intellectual fatigue, irritability, myalgia, at intensive physical and intellectual activities, during pregnancy. the hypomagnesiemia which arose owing to long smoking and an alcohol abuse, prolonged use of laxative, contraceptive means, some diuretics or as a result of an osmotic diuresis at patients with diabetes with a constant hyperglycemia.

Use

Dose of medicament of a biolektr magnezium forte depends on degree of deficiency of magnesium in an organism. the average daily dose makes 1–2 sparkling tablets (243–486 mg of ions of magnesium = 10–20 mmol).

appoint on 1 sparkling tablet of 1 times a day.

to Teenagers and adults are appointed on 1 tablet by sparkling 1–2 once a day.

At heavy degree of deficiency of magnesium the medicament Biolektra Magnezium forte in higher doses.

Tablet needs to be dissolved in a glass of water, to drink the received solution.

Duration of treatment depends on the reasons which are the cornerstone of deficiency of magnesium.

in high doses under observation of the doctor.

Contraindication

Hypersensitivity to medicament components. medicament is not recommended to be used in a renal failure and disturbances of conductivity of excitement in heart (av-blockade of high degree) which can lead to bradycardia. it is necessary to check whether there are disturbances of mineral and electrolytic exchange (a gipermagneziyemiya, a hyperpotassemia). medicament of a biolektr magnezium is forte contraindicated at a heavy myasthenia, an eksikoza and calcium-magnesium-phosphate - ammonium diathesis.

At higher doses the slight diarrhea which is not considered dangerous and disappears after a dose decline is possible

. at long administration of medicament of a biolektr magnezium forte in high doses the fatigue can appear. in that case the doctor has to make the decision on expediency of further use of magnesium on the basis of clinical and laboratory trials.

Special instructions

1 tablet sparkling contains 7.35 mmol (169 mg) of sodium. the patients keeping to a diet with the low content of sodium / table salt need to consider it.

1 tablet sparkling contains 3.48 mmol (136 mg) of potassium. Patients need to consider it with impaired renal function and also to the persons adhering to a diet with the low content of potassium.

Use during pregnancy and feeding by a breast. During pregnancy and feeding by a breast there are no risks of use of drug.

Children. Drug is not recommended to be used to children under 6 years.

Ability to influence speed of response at control of vehicles or work with other mechanisms. Does not influence.

Interaction

At simultaneous use of iron, sodium fluoride or tetracycline the absorption of iron, sodium fluoride, tetracycline and magnesium can be broken. in such cases between administration of medicament of a biolektr magnezium forte and iron preparations, sodium fluoride, tetracycline it is necessary to observe an interval of 3-4 h

At a concomitant use of the medicaments containing aluminum (for example antiacid means), absorption of aluminum can raise.

is Strengthened by influence of antiarrhytmic, hypotensive medicines, reduces degree of deficiency of magnesium and risk of the complications connected with it at intake of diuretics, aminoglycosides, Cisplatinum, cyclosporine, Amphotericinum, a methotrexate, laxative drugs.

Overdose

At use of salts of magnesium inside the gipermagneziyemiya arises only in a renal failure. intake of salts of magnesium is contraindicated to these patients.

intoxication Symptoms. High concentrations of magnesium cause relaxation of skeletal muscles (concentration of magnesium in blood plasma of 5.5 mmol/l). Concentration of ions of magnesium of 10-20 mmol/l extend the conductivity period in heart, and higher concentrations lead to cardiac arrest in a diastole.

Treatment in intoxication. In/in administration of calcium instantly leads to stopping of the described symptoms as there is an antagonism between ions of calcium and magnesium.

Storage conditions

In original packing at a temperature not above 25 °C.

Exclusive distributor: CIAO Naturfarm, Lesnaya St., 30a, Kiev, Pushcha-Vodytsia, 04075; phone number: (044) 401-81-03.

Supplier: Alpen Pharm AG (Switzerland).